Vine cultivation, already known to the Gauls, was widely developed by the Romans. Monks were the first to clear the land and cultivate these vineyards and Bishops were instrumental in extending vine cultivation. In 1157, in keeping with Roman tradition, Geoffrey, the Bishop of Avignon, planted vines and personally managed his own estate and was most certainly the owner of a vineyard located in his fief in Châteauneuf.
Under Pope John XXII, wine from Châteauneuf was regularly supplied to the Papal residence. John XXII was beyond doubt the prelate who participated most in developing the reputation of Châteauneuf-du-Pape wines and his legacy, the first appellation in the history of Châteauneuf, was the prestigious appellation of "Vin du Pape" that was later to become "Châteauneuf-du-Pape ".
At the end of the last century, Joseph Ducos grouped together on his estate ten carefully selected grape varieties. Even then, the characteristics and flavours of Châteauneuf wines were very varied and, like all Rhône Valley wines, generous.